*Spoilers for Book of Mormon below*
When I saw The Book of Mormon in Chicago about a week ago, one moment of dialogue in act 2 got a moment of laughter that evolved into applause, specifically the scene where the other villagers tell Nabulungi how obvious it was that Arnold's stories were made up and ridiculous.
Also, when I saw Spamalot in Detroit a few years ago (during the heart of a scandal with Kwame Kilpatrick, a mayor who got into a fight with a sex worker among many other things), the Knights who say Ni reintroduce themselves in a nonsense word ending with "Kwame is in texas." Then adding that he'll probably return, as strippers fight back there. The line got so much laughter and applause that it stopped the show for a solid minute.
What are your favorite moments like this?