Hey and while we're at it....Chris Sarandon as Humperdinck...and hey Billy Crystal is almost old enough to play Miracle Max without any make-up!
Seriously...assuming this project comes to fruition in the next few years I could see maybe a Douglas Sills or Mark Kudisch as Prince Humperdinck and Kelli O'Hara as Buttercup. I could see Esparza as Inigo, although it would be hard to fill Patinkin's shoes (or get his image out of my mind). With Andre the Giant being such a unique individual, and that role tailored exactly for him--who could play Fezzik? Enormously huge, but still come accross sweet and innocent? Cheyenne Jackson? Burke Moses?
"You pile up enough tomorrows, and you'll find you are left with nothing but a lot of empty yesterdays. I don't know about you, but I'd like to make today worth remembering." --Harold Hill from The Music Man