Obama's speech was the standard bearer. Irreverent, delivered with an effortless insouciance that we seldom see. His targets were many and varied (including himself, almost my favorite part: "you're dumb!" was his response to charges of his arrogance), and in even taking on the audience he channeled his inner Gervais. If you're already a fan you could only love him even more.
"I'm a comedian, but in my spare time, things bother me." Garry Shandling