Personally, I can't handle Fremont Street for more than about an hour. Take some photos, watch the big video screen above, then get the hell out of there. Most of it is shabby and creepy. Ditto that for Stratosphere and Circus Circus.
Though most of the attractions are on the strip, objects on the strip are farther than they appear, especially if you're walking, so budget time and energy accordingly. The monorail on the east side helps a bit, but the stations are in the back of the resorts and just walking throught them to the front to get to the strip can still be more of a hike than you might think. And Caesar's Palace alone can eat up most of one day. Did they ever repair the robot fountains in the mall? Last time I was there, none of them were working properly and they were a huge waste of time.
FYI...There is a great little bar upstairs at Bellagio with a terrace. Try to get there at dusk and snag a table on the terrace in the front. Then relax with drinks as the sun sets and you get a glorious view of the fountains.
The last time I was in Vegas, the Encore had just opened and we got a great deal on a suite. The Wynn/Encore became my favorite and now I wouldn't want to stay anywhere else. Both Wynn and Mandalay Bay had my favorite buffets. And surprisingly, my favorite casino turned out to be at the Planet Hollywood hotel.
"What can you expect from a bunch of seitan worshippers?" - Reginald Tresilian