You could do it if your plane arrived on time and you did not have checked luggage. If you take the Air Tran and E train (at Jamaica Station) combination to Times Square it will take approximately one hour, fifteen minutes. A little shorter or a little longer depending on the subway train. You have to walk a good distance before you catch the AirTrain. You would have to walk double time. There are a couple of baggage storage companies in Times Square. They are not that expensive. But that may take about 20 minutes of your time. Another alternative, is for someone on here, to suggest a hotel close to those theaters, who have "friendly" luggage men who would not turn down a $10 tip to hold your luggage. Just say, you have somewhere to be and will check into hotel later. Then after the show, get your luggage and exit to your transportation to Harlem. My concern for you would be, checking into your hotel so late. As long as they know, you may not be there to check in until 10:30/11:00 and don't give away your rooms. You may want to wait until you are actually at the theater to purchase your tickets. Your options may not be as good or more expensive, but at least if something goes wrong you didn't waste money on the tickets. It can be done. Once flying into Laquardia on a Saturday afternoon, my plane was late. Shared a cab and bought my standing room ticket in less than 40 minutes from getting off plane. Made the curtain by 10 minutes. Of course, that is a different airport.