Lead Replacements

I've a question spurred by someone's post. I've never revisited a show specifically because the lead changed, but I see a lot of theater fans do. I'd love to hear from folks who've gone back for the the switch and how that affected their experience of the show. I saw the Sweeney Todd revival when Judy Kaye was subbing and she was amazing, BUT I'm sure it was very different with Madame Lupone. And info about specific plays/replacements would be great for the conversation.

I love to repeat shows with different actors and I confess I too have recently seen a number of Matildas and Miss Trunchbulls with a bunch of diff Wormwood Parents, etc... a number of Neverland kids in various roles along with 3 different Captain Hooks, 2 Barries, 2 lead actors at Curious Incident, 3 different Lolas & 3 Charlies & Laurens at Kinky Boots. They are the first ones come to mind (there are more for sure). I certainly enjoyed some more than others but I don't feel comfy badmouthing or even comparing one actor to another at the expense of another (not that you were asking us to) for the most part...

The biggest thing I have noticed is that the actual running time of a show may change with a different lead actor - because the applause, audience reaction to jokes, timing of dialogue, etc may lengthen or shorten a particular performance.