There's Jekyll and Hyde, which has two major female parts (Lucy and Emma) plus several smaller ones (Lady Beaconsfield and another prostitute whose name I can't remember...) and other women are needed for the scenes in the Red Rat.
For men, there's Jekyll/Hyde, Simon Stride, Danvers, and Utterson, who all have significant lines/singing, plus other men on the Board of Governors
The ensemble is involved in Facade, which is one of the first numbers, the several reprises of Facade that occur, and Murder Murder (the opening of Act Two)
Please, don't let me be normal!