You cannot gauge a shows success or failure by geographic location alone, where the Lunt Fontanne is, must be the prime location on Broadway, yet the theatre hasn't originated a hit show since Sound of Music.
MarkBearSF said: "As for PRINCE OF BROADWAY, why do I think that the Shuberts were involved. If so, would it be going into a Nederlander house?
As for "flop houses" - I DO believe that the theaters off the beaten track (like in EBroa - as Hedwig put it) may have a slightly harder time with spur of the moment sales - especially at TKTS, where "out of sight, out of mind" may be a factor. (However, perhaps aside from CHICAGO, being a hit at TKTS is not a way to make money). The first time I visited the Neil Simon was to see HAIRSPRAY, which was a big hit. Each house has its characteristics which make it better suited for some productions than others. Not only size, but stage/wing/fly space, pit space, and yes, location.
As to being too far north, yeah a whole block further than the much larger Gershwin, which certainly hasn't had a problem for the past dozen years.
"