Taking busses OUT of Boston is a lot easier then back. I would only suggest: Megabus, Bolt or Greyhound....although Greyhound has the most trips and had become much more reliable then the others. Returning to Boston, I suggest ONLY using Greyhound, especially with luggage, for 2 reasons: 1. the others have street pickup and Mega, in particular, is a pain to get to with luggage. You are also stuck outside regardless of the weather conditions. 2. Neither Mega or Bolt have many offerings past early evening.
All of them allow luggage, but I don't know if there are limits. (and since the luggage goes underneath, size isn't an issue.
If we're not having fun, then why are we doing it?
These are DISCUSSION boards, not mutual admiration boards. Discussion only occurs when we are willing to hear what others are thinking, regardless of whether it is alignment to our own thoughts.