There is a 1930's Walter Huston and Ruthe Chatterton movie called "Dodsworth". It is fantastic! I know Stephen Cole staged an adaptation of the work in Dallas in 1994, but the last I heard, the name's been changed to "Continental Divide" and it's not in the works.
It centers on a man who is retiring from business, his snotty wife who is afraid of aging, and a cruise to Europe that changes both their lives (and Mary Astor's).
Wonderful 1930's movie, with dead on acting, snappy dialogue and truly believable situations. Also a fantastic book, but I am not sure if anyone had staged it before the 1936 movie.
"My dreams, watching me said, one to the other...this life has let us down."