I live part of the year in Sarasota, FL, which is dubiously referred to as the 'art capital of Florida'. In Sarasota alone, they have a large theatre that handles national tours, and three really excellent regional theatres. One of them, the Asolo, has put on a number of productions which I felt were as good as the originals...Josh Rhodes directed productions of Cabaret, Evita and Crazy for You that I honestly felt were better than the Broadway productions (he had the advantage of being able to take advantage of the original ideas and then add his own concepts....the results were great. Many excellent productions have been presented over the years. There is then the added advantage that the theatre seats about 700 people, I imagine, so you are relatively close in even the cheapest seats.
I have seen many touring productions over the years. They were very professional, well cast, and they generally were slightly to very scaled-down versions of the Broadway productions. If you see the show in Tampa, you are in a barn, and you don't have to be very far back to feel that you are really too far from the stage. I cannot even imagine seeing a small show in that barn, e.g., Kimberly Akimbo. In Sarasota, not quite a barn, but a theatre with a lot of bad seats IMO.
So, all things considered, the intimacy of the regional theatre wins for me every time.