I loved South Park, but then it just kept trying to top itself and it grew tiresome. I go back and watch it occaisionally, but not as faithfully as I used to. I tried watching Family Guy, but I couldn't get into it. It reminds me of a mixture of Rugrats, South Park and The Critic. It was too unfocused for me and seemed to try and pack in as many irrelevent comments per minute rather than being actually witty. That, and I couldn't stand the animation. But maybe I'll try it again...
I liked The Simpsons for the first couple of seasons, but then it seemed to be the same thing over and over again, so I stopped watching. I prefer Over the Hill. Growing up in Texas, I could easily relate to the show. All the characters remind me of all my aunts, uncles and cousins.
"What can you expect from a bunch of seitan worshippers?" - Reginald Tresilian