"Wonder if they will try to get Louise Pitre for the Bev Bass role"
They announced the cast a while ago, and they are all listed at Tag's link. If i recall the newsletter correctly, I think Lisa Horner is the one playing Bev and others.
Regarding length of the open-ended run, it is playing in the same (small-ish) theatre where Kinky Boots did their sit-down with the Canadian cast, and that run lasted about a year (11 months, maybe?).
I'd be quite surprised if Come From Away didn't last significantly longer than that. It sold out its first subscription run a lot faster (before lots of subscribers even saw it for the first time), so there were lots of subscribers who saw it on subscription, wanted to go back and see it again and/or bring their friends, but couldn't because there were no more tickets for the entire run. I went back to KB a few more times, each with different groups of friends who wanted to see it, and it was never hard to get tickets. CFA was in such demand that they offered SRO for the first time that i heard about in 11 years of living in Toronto. So i'd predict at least a 2-year run, maybe even 3 or 4, but then again, "prediction is hard, especially about the future" (Yogi Berra or Neils Bohr; i've heard both attributions in different sources).