Arsenic and Old Lace comes to mind, but it requires a bit of a set--you can work around it. I'm literally performing it right now in a trailer...we've made it work.
Kimberly Akimbo is great- but that's like, a five person cast...and boarderlining on dark, though it is VERY funny :P
I'm surprised no one has suggested Brighton Beach Memoirs yet.
Recent Broadway and Off-Broadway:: Carrie, Merrily, Ionescopade
Next On The List :: Clybourne Park, Once, Streetcar, BOM