Pal Joey, circa 1976
Edward Villela (as Joey) played the first preview, a Friday, and said "No more". He was gone. Eleanor Parker (as Vera) played through Sunday afternoon, 4 performances, and also 'ankled' as Variety used to put it.
The understudies, Christopher Chadman and Joan Copeland, played the run which got lethal reviews.
More Joan Copeland: about the same time as Pal Joey, say a year either way, there was a disaster called Dr. Jazz at the Winter Garden that played about 6 weeks of previews and 5 performances. Joan Copeland had a featured above-the-title-billed role. Sometime about 3-4 weeks into the preview period, Ms. Copeland said to the effect, "This is ridiculous. The show is a mess and they keep cutting my role", so she 'ankled'.
I forget who took over, but I remember that the show had so little money in the till that they splashed paint that didn't match at all quite unartistically over Copeland's name on the front-of-the-house posters and never repainted the new actress's name in.
PS - Joan Copeland was Arthur Miller's sister.
"If my life weren't funny, it would just be true. And that would be unacceptable."
--Carrie Fisher