I've never seen anything outside of the tours of the original production so I would have to say that the best of those (to me) was the 2003 non-equity cast. It may have been because it was the height of my obsession with the show but it was during a time when the fanbase seemed to collectively agree that the Broadway production had gone a little stale with a lot of career Rent actors rotating in and out, and the non-equity production had recently reopened with a cast of energetic unknowns. The cast included a pre-Idol Constantie Maroulis as Roger, Rebecca (Pre-Naomi) Jones as Joanne (and the Mimi u/s), and later on Aaron Tveit (but I can't remember if he came along with the group that started in the 2004 cast). Again, I fully admit the nostalgia-goggles are firmly fixed to my face but not even seeing Anthony and Adam in their original roles matched that cast for me.
For perspective, I saw 3 different casts with that non-equity tour (The Collins Tour) in 2003, 2004, and 2006 (I think) in addition to the Broadway Tour with Adam Pascal, Anthony Rapp, and Gwen Stewart reprising their OBC roles, and the 20th Anniversary Tour when it opened in Lexington last year.
"Who says you can't bend over backwards and eat bugs if you want to? I guess the bugs would probably say you can't do that that, but assuming that they are willing and consenting bugs, then there's no problem. Let's wig out eating bugs."
-RuPaul