My predictions: Beetlejuice will be an immensely divisive musical, just as it was a divisive movie. The film is brilliant as an impressionist art piece, and the characters are all vivid, but the plot is not only nonsensical but completely falls apart at the climax. Mostly, Beetlejuice on film is a series of outrageously conceived, high camp set pieces.
The trouble with this is, if you give it a more linear plot (like the original screenplay, which press releases hint this musical is drawing from), people who liked the shambling stream-of-consciousness quality of the film will hate it. And if you continue to play all loosey-goosey with the plot, that won't make for a very solid musical, and you can't run a show on a singular artistic vision and a prayer as well as you used to.
It'll play, people will have mixed feelings and deep passions about it one way or another, but a large number of people will just ignore it, because (like HEATHERS) the material is simply not to many people's tastes. And like HEATHERS, it'll do really well in regionals despite not really sticking around long in NYC.