I like the idea of Midler, though I guess she'd only consider it on film rather than stage. I could see her as a combination of the comedy that Rosalind Russell brought to Auntie Mame, mixed with the star power required for the songs. I think Jane Lynch would make a good Vera, and I'll suggest Rachel Dratch as Gooch.
"It does me no injury for my neighbour to say there are 20 gods or no god. It neither picks my pocket, nor breaks my leg."
-- Thomas Jefferson