If anyone on the series has a chance of an acting nomination it is Anjelica Huston in the supporting category but she won't win (Maggie Smith will win for Downton Abbey).
There is too much competition in the lead actress category for Debra Messing to sneak in (Glenn Close, Claire Danes who is the probable winner, Mireille Enos, Mariska Hargitay, January Jones, Julianna Margulies, Elizabeth McGovern, Elisabeth Moss, and Kyra Sedgwick).
The series should (and will) get quite a few nominations in the creative arts categories (musical scoring, song(s), art direction, costume design, film editing, etc.).
Updated On: 5/13/12 at 08:59 PM