The original Michael Blakemore production (with Dorothy Loudon, Victor Garber, Brian Murray et al) was one of the most consistently funny comedies that I've ever seen, with the comedy building act to act to act. However, the Jeremy Sams revival from a few years ago (with LuPone, Peter Gallagher, Faith Prince, TR Knight, Katie Finneran, Richard Easton et al) definitely had pacing problems and a certain unevenness in the ensemble.
Farce is all about detail and timing and requires clockwork precision from the direction and performances (and, by the way, half of the laughs are NOT on the page). Without that, the humor will inevitably fall flat for long stretches at a time. The performers also have to know when to underplay, when to overplay, when to move and when to stay absolutely still (so as not to step on a joke in another part of the scene), when to emphasize and when to throw something away. It's a very subtle alchemy and going slightly too far in any one direction can kill laughs left and right.
It really all goes back to the direction. Blakemore was an absolute master and created one the funniest comedies Broadway has seen in decades. However, productions I've seen from Sams and others were entirely hit or miss and I would bet that that was the main problem with the production you saw tonight.
"What a story........ everything but the bloodhounds snappin' at her rear end." -- Birdie
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"The Devil Be Hittin' Me" -- Whitney