Jason Alexander has directed a few plays in LA to generally unehthusiastic reviews. I'm anticipating he'll see this production as sa chance to prove himself as a director. I'm sure Kelli would love to play dot in the Broadway transfer of the London production (As fabulous as Jenna Russell was in the London production, American producers will want a pedigreed Broadway actress for the role).
Will Neil Patrick do the role in LA? I'm not sure he can afford t take time away from his sitcom's shooting schedule. I personally think James Barbour would be an ideal choice (he has a "cold" quality that would be perfect for the role). Mark Kudisch isn't available but he would have been perfect.
Malcolm Gets is a Reprise "regular" but I think he would be totally wrong as George.
Another interesting choice would be Hugh Panaro who did Merrily in concert at Reprise a few years ago.
"It does what a musical is supposed to do; it takes you to another world. And it gives you a little tune to carry in your head. Something to take you away from the dreary horrors of the real world. A little something for when you're feeling blue. You know?"