It's an interesting debate.
Having done roles in well-known pieces as well as created things from scratch, I have to say that the 'unknown factor' in a new piece is probably the toughest part. In an established piece like Company, you know that it works...on a very basic level. Also, the emotional arc has already been charted for the role. Now, one can choose to go against what's come before or to do a new interpretation. But, in the end, the safety net of 'This has worked before' is there.
In a new piece, that doesn't exist. It's really walking the wire without a net. It's terrifying...and thrilling.
That said, should that come into play when deciding the Tony? The award is called Best Performance by an Actor in a Leading Role in a Musical, not Best Performance by an Actor in a Leading Role in a Musical Who Had the Toughest Job.
"I'm so looking forward to a time when all the Reagan Democrats are dead."