I think that Megan Hilty would do terrif as one of the three "wards". (She's a bit too "Cupie doll" to be Nanette. And I don't mean "Cupie Doll" as an insult.) If she wouldn't consider it a step down from being the third replacement lead in a hit show.
I'll take JohnBoy2's word on John Driscoll as Tom. He's certainly easy on the eyes.
Yes, Elaine Stritch would be divine as Pauline. But she's too big a talent to waste in such a small part. It would be like asking Rembrandt to paint the label of a pickle Jar. Not to say that Kaye Ballard is any less of a talent, but she has already played the part for Goodspeed.
And I would say that if we go in for color-blind casting, Leslie Uggams would make a good Lucille. She may be in her sixties, but looks fifteen years younger, at least.
"A coherent existance after so many years of muddle" - Desiree' Armfelt, A Little Night Music
"Life keeps happening everyday, Say Yes" - 70, Girls, 70
"Life is what you do while you're waiting to die" - Zorba