As for regional productions and tours, I've walked out of several. Most recently, the national tour of Newsies. I'm a fan of the film and the score, but I found almost nothing likable in the stage production.
Broadway: Priscilla, Queen of the Desert. What made the film so brilliant was the juxtaposition of the drag queens against the bleak backdrop of the outback, which crossed over to the characters they encountered along the way. When you remove that backdrop and make everything on stage the same level of the color and camp as the drag queens, the contrast is gone and it's just all bright, loud and gawdy all the time. Left at intermission with a pounding headache.
West End: In a Forest Dark and Deep (preview). There was no intermission and no aisles, so about 20-30 minutes into the show, I climbed over people unwilling to let me out and when I passed Neil LaBute at the end of the row (who was also the director), I told him it was a steaming pile of sh*t. It was two detestable characters hinting at a "shocking" reveal that you could see coming from a mile away, basically behaving like LaBute characters, bolstered with cliched foreshadowing as subtle as a sledgehammer. Admittedly, I was already in a REALLY bad mood and was hoping the play would serve as escapist entertainment, but it just made the world so much WORSE.
"What can you expect from a bunch of seitan worshippers?" - Reginald Tresilian