Yes, they are "cursed" and the poster who called it a vicious circle pretty much hit the nail on the head. The shows that are really wanted get the prime theatres. The ones that are thought to be bridesmaids, get what's left.
Also remember than the Cort in the early 70s was used as a tv studio by CBS for Merv Griffin's late night talk show; the Miller's/Sondheim was a porn house then a disco before it was demolished and rebuilt behind the original facade; the Hudson became part of a hotel; the Belasco had it's orchestra seats removed for about 4 years with the idea of it becoming a cabaret and its boxes were restored only this year; and the Playhouse which was across 48th St. from the Cort, the 54th St/Abbott on 54th between 6th and 7th and the original Ziegfeld at 54th and 6th were torn down.
Of these houses, the Playhouse was actually sought after. In the 60s, its last decade, it housed two major comedy hits that each ran over two years, Never Too Late and The Impossible Years. This is the theatre used in the original film of The Producers.
The hits that have played the east of Broadway theatres have often been limited runs. Occasionally a commercial show will come in and will get a real run, but not all that often.
William Goldman in The Season addresses this issue and while things have changed, they haven't changed all that much.
"If my life weren't funny, it would just be true. And that would be unacceptable."
--Carrie Fisher