If you can take it (and really, it's not that hard) I would go with standing room. I did SRO for Les Miz the Friday of Thanksgiving weekend and couldn't have been happier. You get the same view as the last row of the orchestra (i.e. the rush seats), you can do it any day of the week (meaning Friday-Sunday as well)...and it just seems like a more reliable way to get a ticket. All I did was walk into the box office at 11:15am to get SRO for the matinee, and it was available. It's also just $21.25--5 bucks isn't a huge savings, but I think it's an extra perk.
All you have to do is stand through the show. You have a nice wall to lean on (though at the Broadhurst I wouldn't recommend it if you are under 5'5") and for me the 3 hours flew right by--I didn't even realize I was standing. Though the SRO section was full when I went, I'm still surprised more people don't consider it when they neat a cheap ticket.
"If there is going to be a restoration fee, there should also be a Renaissance fee, a Middle Ages fee and a Dark Ages fee. Someone must have men in the back room making up names, euphemisms for profit."
(Emanuel Azenberg)