Not a fan of Michelle Pfeiffer's bleating vibrato, so I would much rather see Streep as Phyllis.
That would put the other principal actors involved in their 60s ... which I feel is too old, but ...
Personally, I would love to see Streep as Sally and Cher as Phyllis, because I would like to see them play off of each other again on screen, and they would attract a film-going audience. They might have to tailor the material a bit to fit their voices and personalities, but I think it would work (well enough).
If Streep is Phyllis, it makes it harder to cast Sally ... maybe Sarandon could do it ... maybe Bette Midler (with the role tailored a bit for her) ...
As for the men, maybe Richard Gere as Buddy and Kevin Klein as Ben ... or vice-versa ...
"Jaws is the Citizen Kane of movies."
blocked: logan2, Diamonds3, Hamilton22