Well, Ljay, clearly some of us think there are different actresses who can play the role beautifully. Megan Mullally is an actress despite being known mainly as a comedienne (clearly the two aren't mutually exclusively) and she can definitely play more than a cartoon. I can see her pulling off the fragility, the romance, and yes even the humor in the role beautifully. I also agree that Mazzie would be a great out-of-the-box suggestion for the part, she's a more natural Phyllis but she's a wonderful actress who would probably have a completely new take on the role. It just sounds like you aren't giving some of these actresses enough credit.
I do think Mullally would make a great, if perhaps a bit predictable, Carlotta.
And bwaylvsong, I kinda love the idea of Reba as Sally!
"Some people can thrive and bloom living life in a living room, that's perfect for some people of one hundred and five. But I at least gotta try, when I think of all the sights that I gotta see, all the places I gotta play, all the things that I gotta be at"