Hough is his pregnant mistress and Delaria is his convict sister who he's pardoning because he's out of his mind. He has a secret health condition that makes it so he can't sit down for the time being and that's the driver of a lot of the problems. The first act is the three staffers dealing with the original problems and the mistress and sister showing up at the White House, causing more problems. Venessa Williams jumps between problem and problem solver throughout the first act.
At the end of the first act, all of the women come together when two different established groups collide. Cooper ends up hidden in a closet and records a VERY incriminating conversation. When she's revealed they all get into a fight trying to steal her phone to erase what she recorded. She throws a bust and hits POTUS in the head. They think they've killed him and the second act is them trying to cover it up while also not creating TOO much suspicion.