"I heard from a source the producers were actually toying around with the idea of having a female Hedwig... Which that kind of 'choice' would seriously depend on the actress, imo"
From an interview with JCM last month:
"In the meantime, I hope Hedwig continues its run on Broadway. Who are some of the performers you’d like to see play the character?
I’d love to see a woman. It would have to be the right woman. I think it wouldn’t have been right to star* with a woman because of what it’s about. We are about artifice and it’s theater and we have a woman playing a man already. I think it works best when you have already had men playing the role so you can add this experience to it. It would have to be the right woman, just as it has to be theright man. I’d love to see Justin Timberlake do it and Lady Gaga. They’re people who have the skills who I don’t think have used them all at the same time in an emotionally substantial piece. They’ve acted well, sang and danced in good things, but this would be putting that all together in something that has a lot of weight to it dramatically. Some of these people we think of as incredible entertainers might find it a great challenge. It would really exciting to see these incredible rock stars really act in something like this."
Since they don't mind skewing younger, now that we've seen a black Hedwig works and doesn't upset the racial dynamic of the Hansel story, I'd kill to see Donald Glover.
I would love to see Juliette Lewis in the role or Jared Leto. Screwing younger and not as well known, I think Scott Hoying (or Mitch Grassi) from Pentatonix would be killer. Not sure about sales, but they'd be amazing.