I went to a Catholic Jesuit high school. I played a musical instrument and was in the orchestra for some other Catholic schools as well. I remember doing WEST SIDE STORY, SOUTH PACIFIC, FINIAN'S RAINBOW, CAMELOT, HALF A SIXPENCE, OLIVER!, FIDDLER ON THE ROOF, ANNIE GET YOUR GUN ("I'm an Indian Too" was cut), MAME, and MAN OF LA MANCHA. I remember other Catholic high schools at the time doing LITTLE MARY SUNSHINE, FLOWER DRUM SONG(!), HELLO DOLLY1, THE KING AND I, DAMN YANKEES, and OKLAHOMA! Okay, this was a while back.
If you're only working with a small group of students THE FANTASTCKS is a great show. IMHO, the less well-known GOD BLESS YOU MR ROSEWATER is another good choice.with a good message.
My alma mater recently did THE WIZ, even though I'm guessing most of the cast was probably Caucasian.
I saw the Encores SUPERMAN. I think it would be hard to pull off, and the portrayal of the villainous Lings is not very PC.