I was in the 100s and it was perfectly fine, though I'd recommend sitting closer to the 200s side of the theater, as most scenes are specifically directed in that direction. There wasn't anything I felt like I missed in particular and the 100s and 300s should be fairly comparable. I suppose a lot of entrances are made on the house left side, so it might be easier to spot from the 300s section, but that's a pretty minor thing. I'd recommend sitting around 3 rows up so you're high enough to see over the actors in case someone is directly blocking someone else, and the theater is intimate enough that even the last row feels very close.
I really loved this show, knowing basically nothing about it going in. I thought the songs were great and suited the actors very well (I really didn't have an issue with Rebecca Naomi Jones that a previous poster mentioned, but it did seem like she might have been a tiny bit sick). Sarah Steele was a definite standout to me, but I also liked Joy Woods quite a bit too, and of course Judy Kuhn gives a great performance.
I think Santino really suits the role of Harry well, with a lot of charm and smarm and smooth talking where you can see why people go along with him. There are a few moments of direct address (which I believe were added in this production) that could've felt clunky and unnecessary (they never really resolve to anything), but they really worked as a way for him to win us over to his side again (though how much of that was Santino and how much of that was Harry, I couldn't really say). I had forgotten how glorious his voice was, so it was a treat to hear it again, especially in the company of such a great all round cast.
I thought the direction was terrific and really utilized the space well. The set is really simple, mostly made up of a bunch of tables and chairs that get moved around with some other pieces that have a nice payoff in the end. There's no stage deck so it really gives the feeling that you're in a workshop or "on the ground", so to speak. The staging specifically for What Are They Doing to Us Now? was fantastic between the movement, lights, and set, definitely a big highlight of the show, and there are certain things they leave in place after the number that affected later scenes in a really subtle way. I'm not sure if it's customary but there's an opening dance sequence performed by Heshy that I thought was beautifully done as well.
I'm not sure how much of the book was revised, and I'd love to hear from someone who knows the original show better, but I thought there were a lot of really smart moments and the story flowed really well. Harry Bogen makes some pretty terrible choices from a moral standpoint, but I think it's clear how he came to make those choices. I also really enjoyed the roles of Ruthie and Martha and how they felt like they could've been stereotypical love interests but broke the mold just enough to feel fresh. And based on the Wikipedia summary, it seems like the ending might have a slightly different touch (also staged beautifully), but the summary is ambiguous enough where I'm not completely sure.