RE seating, I was in front row Mezz near the side--probably 5 seats off the last aisle. I will say that if you are in those box seats House right, you will miss Austin Pendleton. DON'T. As others have said, he's one of the bright shining moments of this show. The problem is, if you choose house left, you'll likely miss Jesse Mueller. The characters are stationary for a majority of the show, so it's really best to see this one as straight on as you can. I had full view of everyone from my seat far Mezz right.
As others have said, it's hard to talk about anything with this show without giving anything away, so read at your own risk.
I'm still processing how I felt about this show. I very much agree with Falsettolands and others: this is a very frustrating play. While moments in Letts' writing are sweeping and beautiful and poignant, a lot of it feels clunky. The cast does a great job with what they're given, especially Armie Hammer and Austin Pendleton. I have a problem with the way some of the characters are written, especially at the end. I don't feel that the play really earned it's ending. Whether that's a directorial or a textual issue though is up for debate. I think it's a little bit of both.
I expected so much from this play, and I don't think it quite lands. Interested to see how it progresses through previews, though.